Current Microwave Chemistryis an international peer-reviewed journal that publishes important contributions describing advances in the use of the microwave in the fields of chemistry, biology, medicine, biomedical science, and engineering. The journal covers microwave-assisted synthesis of novel organic, organometallic and inorganic molecules or complexes, kinetics and mechanistic studies of microwave-induced chemical reactions and potential use of microwave irradiation in the fields of drug discovery, green chemistry, catalysis and industrial process development. It is the premier source of microwave related information for chemists, biologists, pharmacologists and engineers in both industry and academia. Read Now: http://bit.ly/2kmlQSs
The recent COVID-19 outbreak has been the main reason behind several temporary school closures around the world. This has made the idea of continuing to pursue educational activities during this time a challenging proposition. The current lockdowns implemented in different countries has forced schoolteachers who wish to complete their current teaching periods to transition immediately to the online classroom. Many schools have already started online classes in the wake of the crisis caused by the global COVID-19 crises. Accessing and managing online teaching resources can be a bit difficult for educators or pupils accustomed to a conventional classroom.
A couple of our authors reached out to us and asked if Bentham Science had a solution for their book, Computer Based Projects for a Chemistry Curriculum – which is a great resource for school and college students and teachers interesting in using computers to illustrate fundamental concepts in chemistry. And we have responded. Starting today up to June 30, Bentham Science Publishers is making the eBook free to download. This means high school teachers and students anywhere in the world can access the content benefit from the projects presented in the book.
Computer Based Projects for a Chemistry Curriculum, authored by Thomas Manning and Aurora Grumatges, presents 24 chapters each giving information about activities employing applications such as MS excel (spreadsheets) and Spartan (computational modeling). Each project is explained in a simple, easy-to-understand manner. The content within this book is suitable as a guide for both teachers and students and each chapter is supplemented with practice guidelines and exercises. The book contents can be accessed here.
We hope that students around the world can benefit from the interesting and informative variety of projects presented in the book, while also allowing educators working in schools to continue their teaching activities throughout the academic year amidst the current pandemic crisis. Stay safe, and happy chemistry learning. Please visit the book page here: http://bit.ly/39uzhTW
Current Nanosciencepublishes (a) Authoritative/Mini Reviews, and (b) Original Research and Highlights written by experts covering the most recent advances in nanoscience and nanotechnology. All aspects of the field are represented including nano-structures, nano-bubbles, nano-droplets and nanofluids. Applications of nanoscience in physics, material science, chemistry, synthesis, environmental science, electronics, biomedical nanotechnology, biomedical engineering, biotechnology, medicine and pharmaceuticals are also covered. The journal is essential to all researches involved in nanoscience and its applied and fundamental areas of science, chemistry, physics, material science, engineering and medicine.
Current Nanoscience also welcomes submissions on the following topics of Nanoscience and Nanotechnology:
Nanoelectronics and photonics
Nanofabrication and measurement
Nanobiotechnology and nanomedicine
Nanotechnology for energy
Sensors and actuator
Computational nanoscience and technology
Articles from the journal: Current Nanoscience; Volume 16 Issue 1
“Journal of Photocatalysis” would publish high quality research papers, reviews, and short communications focused on photocatalysis from many different scientific areas including Chemistry, Chemical Engineering, Materials Science, Materials Engineering, Environmental Engineering, Nanotechnology and Green Chemistry.
“Journal of Photocatalysis” would accept novel papers in the following fields:
Preparation and characterization of new photocatalysts.
Photocatalytic elimination of environmental pollutants in liquid or gas phase.
Photocatalytic syntheses of valuable products.
Photocatalytic hydrogen generation and CO2 reduction.
Kinetics and mechanistic aspects of photocatalytic reactions.
Combination of photocatalysis with other technologies, such as membrane technologies and photoelectrocatalysis.
Engineering aspects of photocatalytic processes.
Theory, modelling and computational aspects regarding the mechanisms of activation of photocatalysis.
Letters in Organic Chemistry publishes original letters, mini-reviews and guest edited issue in all areas of organic chemistry including synthesis, bioorganic, medicinal, natural products, organometallic, supramolecular, molecular recognition and physical organic chemistry. The emphasis is to publish quality papers rapidly by taking full advantage of latest technology for both submission and review of the manuscripts.
The journal is an essential reading for all organic chemists belonging to both academia and industry.
Articles from the journal Letters in Organic Chemistry, Volume 13 Issue 3:
Synthesis of 1,8-Dioxo-Decahydroacridines using Pyridinium Hydrogen Sulfate Ionic Liquid as an Green, Efficient and Reusable Catalyst
4-(1-Adamantyl)phenylalkylamines with Potential Antiproliferative Activity
Easy Removal of N-carboxybenzyl (Cbz) Protective Group by Low- Carbon Alcohol
Spectroscopic Properties and Preparation of Some 2,3-Dimethoxybenzamide Derivatives
Efficient and Selective N-, S- and O-Acetylation in TEAA Ionic Liquid as Green Solvent. Applications in Synthetic Carbohydrate Chemistry
CaF2 Catalyzed Chemoselective Oxidation of Sulfides to Sulfoxides with Hydrogen Peroxide Under Solvent-Free Conditions
Microwave-Assisted Synthesis of Novel Bisspiropyrrolidine Thiochromanone Derivatives and Antifungal Activity
Stereoselective Cyclopropanation Under Solvent Free Conditions: Catalyzed by a Green and Efficient Recyclable Cu-Exchanged Bentonite
An Efficient Three-Component Reaction of Sodium Azide, Haloalkane and Alkyne for the Synthesis of 1, 2, 3-Triazoles Catalyzed by the Bifunctional Ionic Liquid Catalyst Choline Chloride-CuCl in Water
New Facile, Eco-Friendly and Rapid Synthesis of Trisubstituted Alkenes Using Bismuth Nitrate as Lewis Acid
Author(s): Anna Munder, Yoni Moskovitz, Boris Redko, Ariel Rachel Levy, Sharon Ruthstein, Gary Gellerman and Arie Gruzman
Affiliation: Department of Chemistry, Faculty of Exact Sciences, Bar-Ilan University, Ramat Gan 52900, Israel. Abstract
We tested the antiproliferative activity and mechanism of the action of several novel aminoacridine derivatives. Six different cancer cell lines were used to evaluate the potential cytotoxic effect of eleven aminoacridine-based molecules. A standard MTT assay was used for cell bioavailability analysis. Additionally, the potential cytotoxic effect of the tested compounds on non-cancer cells was investigated in rat skeletal muscle myotubes (L6) and in bovine aortic smooth muscle cells. In order to investigate whether the DNA binding activity of tested compounds correlated with their cytotoxic effect, circular dichroism (CD) measurement and DNA T4 ligase assay were performed. Finally, the potential mutagenic activity of the lead compound 5 was investigated.
The cytotoxic effect of compound 5 in cancer cells was obtained in lower concentrations than the well-known: 9- aminoacridine based drug, amsacrine. The lead compound binds to DNA, but in a different mode than the parent molecules. Additionally, compound 5 was not cytotoxic in the effective range of concentrations in non-cancer cells. In identical concentrations, the parent compound (9-aminoacridine) and amsacrine were extremely toxic for both types of these normal cells. Finally, based on CD measurement and T4 ligase assay, it was confirmed that 5 binds to DNA but in different from the parent compounds manner. Important to mention, that compound 5 might have increased mutagenic activity which must be verified in vivo.
Based on these in vitro results, we conclude that 5 is a more potent and more selective antiprolifirative compound than amsacrine. Compound 5 was also more effective in HepG2 and P-12 cells. Thus, 5 is suitable for future in vivo biological evaluation and its structure might be used as a basis for developing novel anticancer drugs.