New Issue | Current Topics in Medicinal Chemistry; Volume 19 Issue 31

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Current Topics in Medicinal Chemistry is a forum for the review of areas of keen and topical interest to medicinal chemists and others in the allied disciplines. Each issue is solely devoted to a specific topic, containing six to nine reviews, which provide the reader a comprehensive survey of that area. A Guest Editor who is an expert in the topic under review, will assemble each issue. The scope of Current Topics in Medicinal Chemistry will cover all areas of medicinal chemistry, including current developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, compound diversity measurements, drug absorption, drug distribution, metabolism, new and emerging drug targets, natural products, pharmacogenomics, and structure-activity relationships. Medicinal chemistry is a rapidly maturing discipline. The study of how structure and function are related is absolutely essential to understanding the molecular basis of life. Current Topics in Medicinal Chemistry aims to contribute to the growth of scientific knowledge and insight, and facilitate the discovery and development of new therapeutic agents to treat debilitating human disorders. The journal is essential for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important advances.

 

Articles from the journal: Current Topics in Medicinal Chemistry; Volume 19 Issue 31

 

 

 

For details on the articles, please visit this link: http://www.eurekaselect.com/node/615/current-topics-in-medicinal-chemistry/issue/19/2599/31/9575

New Issue | Current Topics in Medicinal Chemistry; Volume 19 Issue 25

 

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Current Topics in Medicinal Chemistry is a forum for the review of areas of keen and topical interest to medicinal chemists and others in the allied disciplines. Each issue is solely devoted to a specific topic, containing six to nine reviews, which provide the reader a comprehensive survey of that area. A Guest Editor who is an expert in the topic under review, will assemble each issue. The scope of Current Topics in Medicinal Chemistry will cover all areas of medicinal chemistry, including current developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, compound diversity measurements, drug absorption, drug distribution, metabolism, new and emerging drug targets, natural products, pharmacogenomics, and structure-activity relationships. Medicinal chemistry is a rapidly maturing discipline. The study of how structure and function are related is absolutely essential to understanding the molecular basis of life. Current Topics in Medicinal Chemistry aims to contribute to the growth of scientific knowledge and insight, and facilitate the discovery and development of new therapeutic agents to treat debilitating human disorders. The journal is essential for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important advances.

 

Articles from the journal: Current Topics in Medicinal Chemistry; Volume 19 Issue 25

For details on the articles, please visit this link: http://www.eurekaselect.com/node/615/current-topics-in-medicinal-chemistry/issue/19/2599/25/9462

eBook Highlights | A Guide to Evaluate Environmental Contaminants and Natural Products

 

This eBook is edited by Ashita Sharma, Manish Kumar, Satwinderjeet Kaur and Avinash Kaur Nagpal published on June 10, 2019. Book URL: https://ebooks.benthamscience.com/book/9789811410963/

 

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Rapid urbanization has pressed the need to assess the environment for the presence of toxic pollutants. Evaluation of Environmental Contaminants and Natural Products: A Human Health Perspective presents a guide to tackle this challenge in two parts which represent two different approaches. The book has two themed parts. The first part of the book summarizes the alarming effects of environmental contaminants. Studies depicting the direct relationship of environmental contaminants with cancer incidence have been referenced. Scientific studies have established an inverse relation between cancer and ingestion of dietary phytoconstituents (phytochemicals) in the form of fruits, vegetables and botanical herbs. Plant products as dietary supplements can suppress contaminant toxicity by regulating the resulting reactive species and also by assisting their bodily excretion through Phase 1 and Phase 2 enzyme metabolism. The second part of the book, shifts focus to phytoconstituents which, if included in diet, can prevent the harmful effects of pollutants. Notes on the anti-mutagenic, anti-genotoxic and anti-carcinogenic potential of many plant products are referenced. The combination of information about contemporary issues of carcinogenic contaminants in the environment coupled with the references to relevant studies in this handbook will enlighten readers studying courses in environmental chemistry, toxicology, botany, and ecology about environmental toxins and help them understand specific dietary measures known to reduce the toxic impact. Researchers in the field of nutrition can also benefit from the information provided. To read out more, please visit: https://ebooks.benthamscience.com/book-highlights/190725001/

eBook | Evaluation of Environmental Contaminants and Natural Products: A Human Health Perspective

 

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BY
ASHITA SHARMA, MANISH KUMAR, SARWINDERJEET KAUR, AVINASH KAUR NAGPAL

Environmental contaminants are constantly increasing in the environment due to the ill planned economic development. Increase in degenerative diseases as a result of continuous exposure to environmental contaminants is posing a serious threat to mankind. While living in such an environment, it has become an absolute necessity to find ways to enhance the protective nature of human metabolic response against the exposure to carcinogens. Various phytochemicals were considered as nectar against many degenerative diseases in ancient civilizations. Modern science is also making efforts to understand the protective effects of natural products. There is a need to compile the information about pollutants which can damage mankind and the protectants to safeguard our existence. The book is a unique and well-arranged compilation of these important aspects.

The first section of the book covers various sources and effects of emerging contaminants in our ambient environment. Environmental contaminants are associated with an increase in incidences of various types of cancers. The chapter entitled “Environmental risk and cancer” covers all such pollutants in detail. Due to the emergence of various contaminants, it has also become important for scientific community to assess the toxicity of various chemical agents present in the environment. Next chapters of the book suggest various plant and bacterial bioassays which could be used to analyze the toxic potential. Injudicious urbanization and economic development have increased the concentrations of some toxins into the environment which could have been prevented if judiciously used; pesticides and biphenyls are perfect examples. In the second section, editors have tried to compile the information about various natural products and their protective effects against carcinogenic potential of environmental contaminants. The metabolic link between plant products and cancer chemoprevention is also summarized well in one of the chapters in the book. The volume of Environmental Contaminants and Natural Products is a concise and well-organized handbook for researchers working in the field. Read out the full version here.

Aims & Scope | Letters in Organic Chemistry 

Letters in Organic Chemistry publishes original letters (short articles), research articles, full-length/mini-reviews and thematic issues based on mini-reviews and short articles, in all areas of organic chemistry including synthesis, bioorganic, medicinal, natural products, organometallic, supramolecular, molecular recognition and physical organic chemistry. The emphasis is to publish quality papers rapidly by taking full advantage of latest technology for both submission and review of the manuscripts.

The journal is an essential reading for all organic chemists belonging to both academia and industry. To learn more about the journal, please visit: https://benthamscience.com/journals/letters-in-organic-chemistry/

 

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New Issue | Current Topics in Medicinal Chemistry; Volume: 19, Issue: 6

 

Current Topics in Medicinal Chemistry is a forum for the review of areas of keen and topical interest to medicinal chemists and others in the allied disciplines. Each issue is solely devoted to a specific topic, containing six to nine reviews, which provide the reader a comprehensive survey of that area. A Guest Editor who is an expert in the topic under review, will assemble each issue. The scope of Current Topics in Medicinal Chemistry will cover all areas of medicinal chemistry, including current developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, compound diversity measurements, drug absorption, drug distribution, metabolism, new and emerging drug targets, natural products, pharmacogenomics, and structure-activity relationships. Medicinal chemistry is a rapidly maturing discipline. The study of how structure and function are related is absolutely essential to understanding the molecular basis of life. Current Topics in Medicinal Chemistry aims to contribute to the growth of scientific knowledge and insight, and facilitate the discovery and development of new therapeutic agents to treat debilitating human disorders. The journal is essential for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important advances.

 

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Articles from the journal: Current Topics in Medicinal Chemistry; Volume: 19, Issue: 6

 

For details on the articles, please visit this link: http://www.eurekaselect.com/node/615/current-topics-in-medicinal-chemistry/issue/19/2599/6/9078

 

 

 

BENTHAM SCIENCE MEDIA PARTNERSHIP for International Conference on Natural Products, Medicinal Plants and Traditional Medicines

 

 

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Natural Medicine 2018 takes immense pleasure to welcome you all to the International Conference on Natural ProductsMedicinal Plants and Traditional Medicines which is going to be held from November 15-16, 2018 at Paris, France.

We gladly invite all the researchers in the field of Natural & Traditional Medicine, herbalists, alternative medicine practitioners and Acupuncturists, Phytomedicine, Pharmacognosists, AyurvedaNaturopathy, people who believe in natural medicine to explore their work. The main objective of Natural Medicine Conference 2018 assembles the Researchers, experts working under Academia and Healthcare industry, Business Delegates, principal investigators, Scientists and Students across the globe to provide an international opportunity for the dissemination of original research ideas, results and practical development experiences.

 

For more details, please visit the conference website: http://naturalmedicine.alliedacademies.com/

OPEN ACCESS ARTICLE – Optimization and Validation of Two High-Throughput Methods Indicating Antiradical Activity – Current Analytical Chemistry

Journal: Current Analytical Chemistry

Author(s): Graciela Granados-Guzman, Ricardo Salazar-Aranda, Marsela Garza-Tapia, Rocio Castro-Rios,Noemi Waksman de Torres

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Abstract:

Background: The search for new natural or synthetic products with antioxidant activity is commonly based on methods that involve reduction of either 2,2-diphenyl-1-picrylhydrazyl (DPPH) or 2-2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS). However, the reported values of the effective concentrations are highly variable, even in controls. Herein, we optimize and validate both methods of determining antiradical activity.

Methods: Optimization was carried out using both a fractionated factorial design and a basic sequential simplex method, by monitoring the reduction percentage. Quercetin or Trolox were used as positive control. Furthermore, for each method, linearity, precision, accuracy, robustness, plate uniformity, signal variability, and Z factor, were established.

Results: The optimized conditions for the DPPH method were: DPPH 280 µM in ethanol and 15 min of reaction time in the dark. The linear range was between 7 and 140 µM with an R2 value of 0.9987. The optimized conditions for the ABTS method were: ABTS adjusted to 0.7 absorbance units, 70% concentration in ethanol, and a reaction time of 6 min in the dark. The linear range was found to be between 1 and 70% with an R2 = 0.9991. For both methods, the accuracy and precision were within limits and the Z factor value was higher than 0.89. The applicability of each method was assessed by analyzing eight plant extracts.

Conclusion: The DPPH and ABTS reduction methods were optimized and validated on a microscale and could be expected to be implemented in any laboratory.

Read more here: http://www.eurekaselect.com/149376/article

HIGHLIGHTED ARTICLE – MYCOSPORINE- LIKE AMINO ACIDS FOR SKIN PHOTOPROTECTION – CURRENT MEDICINAL CHEMISTRY

Cmc-Articles_24-42-Karl P Lawrence

To access the article, please visit: http://www.eurekaselect.com/152756/article

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